clinical pattern

TH2 / Allergic Pattern

IgE, mast cells, eosinophils, epithelial alarmins, and type 2 repair biology

allergyIL-4IL-5IL-13IgE

Review layer

Last reviewed 2026-05-17

well-supportedclinical context required

Use as a systems teaching model for type 2/allergic inflammation. Clinical interpretation depends on phenotype, tissue context, exposure history, and biomarkers.

3 review sources

Type 2 immunity in allergic diseases Epithelial cell-derived cytokines: more than just signaling the alarm Interleukins 4 and 13 in asthma: key pathophysiologic cytokines and druggable molecular targets

State signature

Systems profile

Inflammation86

Tolerance45

Metabolism54

Tissue88

Neuroimmune38

Chronicity48

Pattern signature

Recognizable immune constellation

Signals

IL-4

IL-5

IL-13

TSLP

IL-33

IgE

Cells

mast cells

eosinophils

basophils

T cell subsets

ILC2

Tissues

lung

skin

gut

Restraint

IL-10

Tregs

SCFAs

vagal tone

barrier restoration

Graph neighborhood

Direct relationships

Full graph

TH2 / Allergic Patternassociated withIL-4

Signature cytokine

TH2 / Allergic Patternassociated withMast Cell

Effector and amplifier cell

TH2 / Allergic Patternassociated withIL-5

Eosinophil arm of type 2 inflammation

TH2 / Allergic Patternassociated withIL-13

Tissue remodeling arm of type 2 inflammation

TH2 / Allergic Patternassociated withTH2 Cell

TH2 cells are the adaptive helper engine of type 2 allergic ecology

TH2 / Allergic Patternassociated withBasophil

Basophils are part of the IgE/type 2 allergic amplification circuit

Pattern logic

Interpretation

Look for barrier disruption, epithelial alarmins, IgE sensitization, neurogenic amplification, and repair/fibrosis drift.

Dominant Signals

IL-4 IL-5 IL-13 TSLP IL-33 IgE histamine

Dominant Cells

mast cellseosinophilsbasophilsT cell subsets ILC2

Tissue Context

lungskingut

Counter Regulation

IL-10TregsSCFAsvagal tonebarrier restoration