cytokine
IL-13
Type 2 tissue remodeling cytokine for mucus, barrier repair, fibrosis drift, and airway reactivity
Review layer
Last reviewed 2026-05-17
Use as a systems teaching model for type 2/allergic inflammation. Clinical interpretation depends on phenotype, tissue context, exposure history, and biomarkers.
State signature
Systems profile
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
IL-13
Targets and effects
Graph neighborhood
Direct relationships
Mucus, airway reactivity, and tissue remodeling
Tissue remodeling arm of type 2 inflammation
ILC2 programs can produce IL-13 during alarmin-rich allergic and repair states
Cytokine ecology
Signal Role
IL-13 acts on epithelial and stromal compartments to drive mucus, smooth muscle reactivity, collagen programs, and type 2 remodeling.
Pathway
Source Cells
Target Cells
Inflammatory Role
Amplifies allergic tissue remodeling, mucus, airway hyperreactivity, and fibrotic repair tone.
Regulatory Role
Supports helminth expulsion and wound repair when self-limited.