Model immune behavior across cells, signals, tissues, and time.

Naive CD4 T Cell

Antigen-inexperienced helper precursor that becomes TH1, TH2, TH17, Tfh, Treg, or memory depending on context

TH1 Cell

IFN-gamma-producing helper state for intracellular pathogens and macrophage activation

TH2 Cell

Type 2 helper state coordinating IgE, eosinophils, mast cells, mucus, and barrier remodeling

TH17 Cell

Barrier helper state that recruits neutrophils and protects against extracellular bacteria and fungi

Regulatory T Cell

FOXP3-positive tolerance cell that restrains activation thresholds and supports resolution

T Follicular Helper Cell

Germinal-center helper cell that instructs class switching, affinity maturation, and B-cell memory

CD8 Cytotoxic T Cell

Antigen-specific killing cell for viral control, tumor surveillance, memory, and exhaustion biology

Eosinophil

Type 2 granulocyte linking parasite defense, allergy, epithelial injury, and repair signaling

Basophil

Circulating type 2 granulocyte linking IgE, IL-4, parasites, allergy, and early TH2 amplification

Monocyte

Circulating myeloid bridge between marrow demand, inflammation, macrophages, and dendritic-like states

Natural Killer Cell

Innate cytotoxic lymphocyte for viral defense, tumor surveillance, missing-self sensing, and cytokine production

Innate Lymphoid Cell

Tissue-resident innate lymphocyte family that mirrors helper T-cell programs without antigen-specific receptors

Dendritic Cell

Antigen-context translator that decides priming, tolerance, and adaptive immune direction

B Cell

Adaptive humoral cell linking antigen recognition, germinal centers, antibody class, and immune memory

Naive B Cell

Antigen-inexperienced B cell that scans follicles and can enter extrafollicular or germinal-center responses

Germinal Center B Cell

Rapidly adapting B-cell state for affinity maturation, class switching, selection, and memory quality

Memory B Cell

Long-lived recall cell preserving antigen experience and enabling rapid secondary antibody responses

Plasma Cell

Antibody-secreting terminal B-cell state with unfolded-protein and survival-niche demands

Regulatory B Cell

IL-10-leaning B-cell state that restrains inflammation and supports tolerance networks

Microglia

CNS-resident macrophage lineage controlling synapses, injury response, sickness signaling, and neuroinflammation

Tissue Resident Immune Cell

Local immune-state category for resident memory, macrophage, mast-cell, ILC, plasma-cell, and stromal-immune niches

IL-1beta

Inflammasome-linked alarm cytokine for fever, pain, neutrophil recruitment, and metabolic inflammation

IL-17

Barrier defense cytokine that recruits neutrophils and amplifies epithelial antimicrobial programs

IL-33

Epithelial and stromal alarmin that lowers type 2 activation thresholds

IFN-gamma

Type 1 cytokine for macrophage activation, intracellular pathogen defense, and cytotoxic immune pressure

IL-5

Eosinophil survival and recruitment cytokine in type 2 immune ecology

IL-13

Type 2 tissue remodeling cytokine for mucus, barrier repair, fibrosis drift, and airway reactivity

TGF-beta

Tolerance and remodeling cytokine linking Tregs, fibrosis, epithelial restraint, and TH17 context

TSLP

Epithelial alarmin that primes type 2 immunity through dendritic cells, mast cells, and ILC2s

GM-CSF

Myeloid survival and activation factor connecting barrier inflammation, dendritic cells, and macrophage tone

CXCL8 / IL-8

Neutrophil recruitment chemokine linking epithelial alarm to acute innate trafficking

Adipose Immune Ecosystem

Metabolic immune niche where nutrient excess, hypoxia, macrophages, and fibrosis reshape systemic inflammation

Liver Immune Ecosystem

Portal immune filter balancing gut-derived tolerance, metabolic stress, acute phase response, and fibrosis

Vascular Immune Ecosystem

Endothelial interface controlling leukocyte trafficking, thromboinflammation, permeability, and systemic cytokine distribution

Lymphoid Tissue Immune Ecosystem

Organized decision architecture for antigen presentation, clonal selection, germinal centers, and memory formation

Bone Marrow Immune Ecosystem

Primary hematopoietic niche where immune supply, plasma-cell survival, trained myeloid output, and inflammatory demand are coupled

Skeletal Osteoimmune Ecosystem

Bone as an immune-active remodeling organ linking osteoclasts, osteoblasts, marrow niches, inflammation, sex hormones, and mineral metabolism

Spleen Immune Ecosystem

Blood-filtering immune organ coordinating encapsulated-bacteria defense, red-pulp macrophages, marginal-zone B cells, and systemic inflammatory surveillance

Mucosal Lymphoid Ecosystem

Tonsils, adenoids, Peyer's patches, and MALT as antigen-sampling hubs for IgA, tolerance, allergy, and barrier memory

Thymus Immune Ecosystem

Central tolerance and T-cell education organ where endocrine signals, epithelial niches, and selection thresholds shape the T-cell repertoire

Endocrine Immune Ecosystem

Hormone-producing organs as immune-modulating tissues linking HPA tone, thyroid signaling, insulin biology, gonadal hormones, and inflammatory thresholds

Neutrophilic / Pyogenic Pattern

CXCL8, IL-1beta, TNF-alpha, emergency myelopoiesis, and tissue containment

TH17 / Fungal Barrier Pattern

IL-17 barrier recruitment, neutrophil support, mucocutaneous defense, and dysbiosis loops