cytokine
TSLP
Epithelial alarmin that primes type 2 immunity through dendritic cells, mast cells, and ILC2s
Review layer
Last reviewed 2026-05-17
Alarmin pages emphasize epithelial and stromal alarm signals as threshold-lowering inputs rather than isolated cytokine facts.
State signature
Systems profile
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
TSLP
Targets and effects
Graph neighborhood
Direct relationships
Epithelial alarmin primes dendritic cells toward TH2 instruction
Keratinocyte alarmin output during itch and barrier stress
Cytokine ecology
Signal Role
TSLP is produced by stressed epithelium and pushes tissue immunity toward type 2 sensitization and allergic inflammation.
Pathway
Source Cells
Target Cells
Inflammatory Role
Promotes allergic sensitization, dendritic cell TH2 instruction, mast cell activation, and ILC2 cytokine output.
Regulatory Role
Can contribute to barrier repair signaling when transient and proportional.