tissue
Skin Immune Ecosystem
Neurovascular barrier where keratinocytes, mast cells, sensory nerves, and resident memory cells shape itch and repair
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Neuroimmune
Nerve, neuropeptide, autonomic, microglial, pain, itch, fatigue, or sickness-behavior coupling.
Chronicity
Memory, priming, fibrosis, exhaustion, remodeling, or other time-dependent drift.
Tissue ecosystem
Spatial immune niche
niche
Skin
Barrier
Cells
Cytokines
Neuroimmune
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
Keratinocyte alarmin output during itch and barrier stress
Context link: no causal arrow.
Skin barrier disruption can recruit IL-17-neutrophil loops that are protective or inflammatory depending on context
Context link: no causal arrow.
Skin resident immune cells support rapid recall, itch, repair, and chronic dermatitis-like niches
Arrow shows upstream source toward receiving target.
Itch and pain fibers can use substance P to couple local neurogenic inflammation with skin barrier reactivity
Immune niche
Tissue Ecology
Skin immunity integrates keratinocyte alarmins, microbial exposure, sensory neurons, vascular leak, resident memory cells, and type 2 or type 17 patterning.