tissue
Skin Immune Ecosystem
Neurovascular barrier where keratinocytes, mast cells, sensory nerves, and resident memory cells shape itch and repair
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
Tissue ecosystem
Spatial immune niche
niche
Skin
Barrier
Cells
Cytokines
Neuroimmune
Graph neighborhood
Direct relationships
Keratinocyte alarmin output during itch and barrier stress
Skin barrier disruption can recruit IL-17-neutrophil loops that are protective or inflammatory depending on context
Skin resident immune cells support rapid recall, itch, repair, and chronic dermatitis-like niches
Immune niche
Tissue Ecology
Skin immunity integrates keratinocyte alarmins, microbial exposure, sensory neurons, vascular leak, resident memory cells, and type 2 or type 17 patterning.