cytokine
IL-5
Eosinophil survival and recruitment cytokine in type 2 immune ecology
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Metabolism
Energy allocation, glycolysis, mitochondrial strain, lipid signaling, or nutrient-sensitive behavior.
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
IL-5
Targets and effects
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
Eosinophil maturation, survival, and tissue persistence
Context link: no causal arrow.
Eosinophil arm of type 2 inflammation
Cytokine ecology
Signal Role
IL-5 is the key cytokine for eosinophil maturation, tissue recruitment, activation, and survival in allergic and helminth-associated inflammation.
Pathway
Source Cells
Target Cells
Inflammatory Role
Sustains eosinophilic inflammation and tissue remodeling when type 2 loops persist.
Regulatory Role
Supports parasite containment and specialized mucosal defense.