tissue
Vascular Immune Ecosystem
Endothelial interface controlling leukocyte trafficking, thromboinflammation, permeability, and systemic cytokine distribution
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
Appears in response traces
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Metabolism
Energy allocation, glycolysis, mitochondrial strain, lipid signaling, or nutrient-sensitive behavior.
Tissue ecosystem
Spatial immune niche
niche
Vascular
Barrier
Cells
Cytokines
Neuroimmune
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
TNF-alpha activates endothelial adhesion and permeability
Arrow shows upstream source toward receiving target.
CGRP is a vasoactive sensory neuropeptide that links trigeminovascular signaling with vascular tone and neurogenic inflammation
Immune niche
Tissue Ecology
The vasculature is an active immune organ where endothelium, platelets, complement, neutrophils, and cytokines determine trafficking and thromboinflammatory risk.