cytokine
IL-1beta
Inflammasome-linked alarm cytokine for fever, pain, neutrophil recruitment, and metabolic inflammation
Review layer
Last reviewed 2026-05-17
Use as a conceptual pattern for innate danger sensing, metabolic stress, and IL-1beta-rich inflammatory states.
State signature
Systems profile
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
IL-1beta
Targets and effects
Graph neighborhood
Direct relationships
Signature inflammasome output
IL-1beta links danger sensing, fever, endothelial activation, and neutrophil-rich inflammation
Cytokine ecology
Signal Role
IL-1beta is generated through priming and inflammasome activation, making it a signature of danger sensing, cell stress, and innate inflammatory thresholds.
Pathway
Source Cells
Target Cells
Inflammatory Role
Drives fever, pain sensitivity, endothelial activation, neutrophil recruitment, and TH17-supportive inflammation.
Regulatory Role
Useful for rapid danger response when time-limited and locally resolved.