cytokine
IL-1beta
Inflammasome-linked alarm cytokine for fever, pain, neutrophil recruitment, and metabolic inflammation
Review layer
Last reviewed 2026-05-17
Use as a conceptual pattern for innate danger sensing, metabolic stress, and IL-1beta-rich inflammatory states.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Metabolism
Energy allocation, glycolysis, mitochondrial strain, lipid signaling, or nutrient-sensitive behavior.
Neuroimmune
Nerve, neuropeptide, autonomic, microglial, pain, itch, fatigue, or sickness-behavior coupling.
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
IL-1beta
Targets and effects
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
CNS danger sensing and sickness signaling
Context link: no causal arrow.
IL-1beta links danger sensing, fever, endothelial activation, and neutrophil-rich inflammation
Cytokine ecology
Signal Role
IL-1beta is generated through priming and inflammasome activation, making it a signature of danger sensing, cell stress, and innate inflammatory thresholds.
Pathway
Source Cells
Target Cells
Inflammatory Role
Drives fever, pain sensitivity, endothelial activation, neutrophil recruitment, and TH17-supportive inflammation.
Regulatory Role
Useful for rapid danger response when time-limited and locally resolved.