reference
NF-kB
Central inflammatory transcription pathway downstream of TNF, IL-1, TLRs, and danger signals
inflammationTNF-alphaIL-1betaTLR
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
pathway
Systems Context
NF-kB is not a disease marker by itself; it is a common wiring layer for many upstream triggers.
Clinical Use
Useful as a hub pathway for inflammatory amplification and anti-inflammatory drug logic.
Aliases
Expressed By
Most immune and stromal cells
Targets
Functions
cytokine inductionchemokine inductioncell survivaldanger response