reference
NF-kB
Central inflammatory transcription pathway downstream of TNF, IL-1, TLRs, and danger signals
inflammationTNF-alphaIL-1betaTLR
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
pathway
Systems Context
NF-kB is not a disease marker by itself; it is a common wiring layer for many upstream triggers.
Clinical Use
Useful as a hub pathway for inflammatory amplification and anti-inflammatory drug logic.
Aliases
Expressed By
Most immune and stromal cells
Targets
Functions
cytokine inductionchemokine inductioncell survivaldanger response