cytokine
IL-17
Barrier defense cytokine that recruits neutrophils and amplifies epithelial antimicrobial programs
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Metabolism
Energy allocation, glycolysis, mitochondrial strain, lipid signaling, or nutrient-sensitive behavior.
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
IL-17
Targets and effects
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
Barrier chemokine programs recruit neutrophils
Context link: no causal arrow.
IL-17 and other inflammatory cytokines can amplify osteoclast-supporting osteoimmune signaling
Context link: no causal arrow.
IL-17 is the signature barrier recruitment signal for fungal and extracellular defense contexts
Cytokine ecology
Signal Role
IL-17 supports fungal and extracellular bacterial defense but becomes pathogenic when barrier or autoantigen loops persist.
Pathway
Source Cells
Target Cells
Inflammatory Role
Induces chemokines and antimicrobial peptides that recruit and activate neutrophil-rich barrier responses.
Regulatory Role
Protects mucosal surfaces when microbiome and epithelial context are balanced.