clinical pattern
Inflammasome Pattern
IL-1beta, macrophage priming, danger sensing, and metabolic stress
Review layer
Last reviewed 2026-05-17
Use as a conceptual pattern for innate danger sensing, metabolic stress, and IL-1beta-rich inflammatory states.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Metabolism
Energy allocation, glycolysis, mitochondrial strain, lipid signaling, or nutrient-sensitive behavior.
No direct axis cue is mapped for this node yet.
Neuroimmune
Nerve, neuropeptide, autonomic, microglial, pain, itch, fatigue, or sickness-behavior coupling.
No direct axis cue is mapped for this node yet.
Pattern signature
Recognizable immune constellation
Signals
01IL-1beta
IL-6
TNF-alpha
CRP
ROS
Cells
02macrophages
neutrophils
monocytes
Tissues
03adipose
liver
gut
vasculature
Restraint
04IL-10
AMPK
autophagy
efferocytosis
resolvins
Graph neighborhood
Direct relationships
Context link: no causal arrow.
Danger sensing and IL-1 family activation
Pattern logic
Interpretation
Map the trigger source: microbial products, urate/cholesterol crystals, hypoxia, mitochondrial injury, or chronic lipid overload.