cytokine
GM-CSF
Myeloid survival and activation factor connecting barrier inflammation, dendritic cells, and macrophage tone
myeloidmacrophagedendritic cellbarrier
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
Inflammation86
Tolerance45
Metabolism54
Tissue88
Neuroimmune38
Chronicity48
Cascade viewer
Source → signal → tissue behavior
Sources
T cells
epithelium
fibroblasts
macrophages
Signal
GM-CSF
Targets and effects
macrophages
dendritic cells
neutrophils
myeloid expansion
barrier inflammation
related: IL-10related: TNF-alpharelated: IL-17related: IFN-gammarelated: IL-13
Graph neighborhood
Direct relationships
Supports inflammatory myeloid survival and activation
Cytokine ecology
Signal Role
GM-CSF supports myeloid cell survival, differentiation, and inflammatory activation, especially in barrier and autoimmune contexts.
Pathway
GM-CSFRJAK2STAT5MAPK
Source Cells
Target Cells
Inflammatory Role
Sustains inflammatory myeloid cell survival, antigen presentation, and tissue cytokine production.
Regulatory Role
Supports alveolar macrophage development and host defense when balanced.
Tissue Effects
myeloid expansionbarrier inflammationalveolar macrophage supportgranulocyte survival
Metabolic Effects
supports active myeloid metabolism and inflammatory persistence
Nervous System Interactions
can participate in neuroinflammatory myeloid activation in chronic disease contexts
Related Loops
T cell GM-CSF -> inflammatory myeloid activationbarrier stress -> GM-CSF -> APC amplification