clinical pattern
Tolerance / Resolution Pattern
Tregs, IL-10, TGF-beta, SCFAs, efferocytosis, and neural restraint
Review layer
Last reviewed 2026-05-17
Tolerance and resolution are modeled as active regulatory programs. Their meaning changes across allergy, infection, cancer, and autoimmunity.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
Appears in response traces
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Tolerance
Immune restraint, resolution, regulatory tone, or set-point control.
Pattern signature
Recognizable immune constellation
Signals
01IL-10
TGF-beta
SCFAs
adenosine
resolvins
Cells
02T cell subsets
macrophages
dendritic cells
Bregs
Tissues
03gut
lung
lymphoid tissue
Restraint
04costimulation
IL-12
IFN-gamma
danger signals
Graph neighborhood
Direct relationships
Context link: no causal arrow.
Tolerance and repair cytokine with fibrosis risk
Context link: no causal arrow.
Regulatory T cells are a central cellular layer of tolerance and resolution
Pattern logic
Interpretation
Assess whether regulation is restoring health, enabling chronic infection, or supporting tumor immune escape.