clinical pattern

Tolerance / Resolution Pattern

Tregs, IL-10, TGF-beta, SCFAs, efferocytosis, and neural restraint

TregIL-10TGF-betaresolution

Review layer

Last reviewed 2026-05-17

well-supportedclinical context required

Tolerance and resolution are modeled as active regulatory programs. Their meaning changes across allergy, infection, cancer, and autoimmunity.

3 review sources

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-beta TGF-beta regulation of T cells Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity

State signature

Systems profile

Inflammation86

Tolerance84

Metabolism54

Tissue88

Neuroimmune38

Chronicity48

Pattern signature

Recognizable immune constellation

Signals

IL-10

TGF-beta

SCFAs

adenosine

resolvins

Cells

T cell subsets

macrophages

dendritic cells

Bregs

Tissues

gut

lung

lymphoid tissue

Restraint

costimulation

IL-12

IFN-gamma

danger signals

Graph neighborhood

Direct relationships

Full graph

Tolerance / Resolution Patternassociated withIL-10

Resolution signature

TGF-betaassociated withTolerance / Resolution Pattern

Tolerance and repair cytokine with fibrosis risk

Tolerance / Resolution Patternassociated withRegulatory T Cell

Regulatory T cells are a central cellular layer of tolerance and resolution

Pattern logic

Interpretation

Assess whether regulation is restoring health, enabling chronic infection, or supporting tumor immune escape.

Dominant Signals

IL-10 TGF-beta SCFAsadenosineresolvins

Dominant Cells

T cell subsetsmacrophagesdendritic cellsBregs

Tissue Context

gutlunglymphoid tissue

Counter Regulation

costimulationIL-12IFN-gammadanger signals