cytokine
TGF-beta
Tolerance and remodeling cytokine linking Tregs, fibrosis, epithelial restraint, and TH17 context
Review layer
Last reviewed 2026-05-17
Tolerance and resolution are modeled as active regulatory programs. Their meaning changes across allergy, infection, cancer, and autoimmunity.
State signature
Systems profile
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
TGF-beta
Targets and effects
Graph neighborhood
Direct relationships
Tolerance and repair cytokine with fibrosis risk
TGF-beta supports regulatory T-cell differentiation and repair restraint
Cytokine ecology
Signal Role
TGF-beta is a context-dependent cytokine that can promote tolerance, restrain inflammation, support tissue repair, or drive fibrosis and TH17 differentiation.
Pathway
Source Cells
Target Cells
Inflammatory Role
Can support TH17 differentiation in IL-6-rich contexts and fibrotic immune remodeling.
Regulatory Role
Promotes Tregs, epithelial restraint, wound repair, and immune tolerance.