cytokine
IL-10
Resolution cytokine that restrains antigen presentation, macrophage activation, and tissue damage
Review layer
Last reviewed 2026-05-17
Tolerance and resolution are modeled as active regulatory programs. Their meaning changes across allergy, infection, cancer, and autoimmunity.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
Appears in response traces
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Tolerance
Immune restraint, resolution, regulatory tone, or set-point control.
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
IL-10
Targets and effects
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
Restrains inflammatory cytokine production
Arrow shows upstream source toward receiving target.
SCFA-rich tolerance ecology
Context link: no causal arrow.
IL-10-rich regulatory tone travels with Treg-mediated tolerance
Arrow shows upstream source toward receiving target.
Regulatory B-cell behavior often depends on IL-10 output
Cytokine ecology
Signal Role
IL-10 is a central anti-inflammatory signal that preserves tissue function by limiting excessive innate and adaptive activation.
Pathway
Source Cells
Target Cells
Inflammatory Role
Indirectly shapes inflammation by preventing over-amplification and collateral damage.
Regulatory Role
Suppresses antigen presentation, inflammatory cytokines, and costimulatory intensity.