cytokine
IL-10
Resolution cytokine that restrains antigen presentation, macrophage activation, and tissue damage
Review layer
Last reviewed 2026-05-17
Tolerance and resolution are modeled as active regulatory programs. Their meaning changes across allergy, infection, cancer, and autoimmunity.
State signature
Systems profile
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
IL-10
Targets and effects
Graph neighborhood
Direct relationships
Restrains inflammatory cytokine production
Resolution signature
SCFA-rich tolerance ecology
IL-10-rich regulatory tone travels with Treg-mediated tolerance
Regulatory B-cell behavior often depends on IL-10 output
Cytokine ecology
Signal Role
IL-10 is a central anti-inflammatory signal that preserves tissue function by limiting excessive innate and adaptive activation.
Pathway
Source Cells
Target Cells
Inflammatory Role
Indirectly shapes inflammation by preventing over-amplification and collateral damage.
Regulatory Role
Suppresses antigen presentation, inflammatory cytokines, and costimulatory intensity.