tissue
Liver Immune Ecosystem
Portal immune filter balancing gut-derived tolerance, metabolic stress, acute phase response, and fibrosis
portal circulationacute phaseKupffer cellfibrosis
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
Inflammation86
Tolerance84
Metabolism82
Tissue88
Neuroimmune80
Chronicity78
Tissue ecosystem
Spatial immune niche
niche
Liver
Barrier
sinusoidal endotheliumbile flowcomplement proteins
Cells
macrophagesdendritic cellsNK cellsT cell subsets
Cytokines
IL-6TNF-alphaIL-1betaTGF-beta
Neuroimmune
vagal metabolic signalingsympathetic hepatic glucose outputsickness behavior via acute phase response
Graph neighborhood
Direct relationships
IL-6 drives hepatic acute phase response
Immune niche
Tissue Ecology
The liver receives microbial and nutrient signals from the gut and translates them into tolerance, detoxification, acute phase proteins, or fibrotic inflammation.
Dominant immune cells
Barrier systems
sinusoidal endotheliumbile flowcomplement proteinsacute phase protein production
Microbiome interactions
portal LPS exposurebile acid signalingmicrobial metabolite detoxification
Neuroimmune interactions
vagal metabolic signalingsympathetic hepatic glucose outputsickness behavior via acute phase response
Cytokine environment
Metabolic conditions
fatty acid fluxglucose handlingoxidative stressER stress