tissue
Liver Immune Ecosystem
Portal immune filter balancing gut-derived tolerance, metabolic stress, acute phase response, and fibrosis
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Tolerance
Immune restraint, resolution, regulatory tone, or set-point control.
Tissue ecosystem
Spatial immune niche
niche
Liver
Barrier
Cells
Cytokines
Neuroimmune
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
IL-6 drives hepatic acute phase response
Immune niche
Tissue Ecology
The liver receives microbial and nutrient signals from the gut and translates them into tolerance, detoxification, acute phase proteins, or fibrotic inflammation.