cytokine
CXCL8 / IL-8
Neutrophil recruitment chemokine linking epithelial alarm to acute innate trafficking
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Metabolism
Energy allocation, glycolysis, mitochondrial strain, lipid signaling, or nutrient-sensitive behavior.
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
CXCL8 / IL-8
Targets and effects
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
CXCR1/2-mediated neutrophil recruitment
Context link: no causal arrow.
CXCL8/IL-8 organizes neutrophil recruitment through CXCR1/2 signaling
Cytokine ecology
Signal Role
CXCL8 is a chemokine that recruits and activates neutrophils through CXCR1 and CXCR2, especially in barrier inflammation.
Pathway
Source Cells
Target Cells
Inflammatory Role
Creates neutrophil gradients and sustains acute trafficking into inflamed tissue.
Regulatory Role
Supports rapid containment of bacterial and fungal barrier breach.