tissue
Brain and CNS Immune Ecosystem
Privileged but responsive neuroimmune compartment governed by microglia, barriers, and sickness signaling
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Neuroimmune
Nerve, neuropeptide, autonomic, microglial, pain, itch, fatigue, or sickness-behavior coupling.
Tissue ecosystem
Spatial immune niche
niche
Brain and CNS
Barrier
Cells
Cytokines
Neuroimmune
Graph neighborhood
Direct relationships
Context link: no causal arrow.
Surveillance can become pathogenic with barrier dysfunction
Context link: no causal arrow.
Primary CNS-resident immune cell
Immune niche
Tissue Ecology
CNS immunity is built around barrier integrity, microglial state transitions, meningeal surveillance, and systemic inflammatory translation into behavior.