tissue
Brain and CNS Immune Ecosystem
Privileged but responsive neuroimmune compartment governed by microglia, barriers, and sickness signaling
microglianeuroinflammationbarriersickness behavior
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
Inflammation86
Tolerance45
Metabolism54
Tissue88
Neuroimmune80
Chronicity48
Tissue ecosystem
Spatial immune niche
niche
Brain and CNS
Barrier
blood-brain barrierCSF barriersmeningeal lymphatics
Cells
microgliaborder-associated macrophagesT cell subsetsmast cells
Cytokines
IL-1betaIL-6TNF-alphaTGF-beta
Neuroimmune
sympathetic tonedopamine-immune interactionsserotonin metabolism
Graph neighborhood
Direct relationships
Surveillance can become pathogenic with barrier dysfunction
Primary CNS-resident immune cell
Immune niche
Tissue Ecology
CNS immunity is built around barrier integrity, microglial state transitions, meningeal surveillance, and systemic inflammatory translation into behavior.
Dominant immune cells
Barrier systems
blood-brain barrierCSF barriersmeningeal lymphatics
Microbiome interactions
microbial metabolites shaping microgliagut-brain immune signalingtryptophan pathway effects
Neuroimmune interactions
sympathetic tonedopamine-immune interactionsserotonin metabolismvagal afferents
Cytokine environment
Metabolic conditions
high mitochondrial demandredox sensitivitylactate signalingsleep-linked glymphatic clearance