tissue
Adipose Immune Ecosystem
Metabolic immune niche where nutrient excess, hypoxia, macrophages, and fibrosis reshape systemic inflammation
metabolismmacrophagehypoxiainflammaging
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
Inflammation86
Tolerance45
Metabolism82
Tissue88
Neuroimmune80
Chronicity78
Tissue ecosystem
Spatial immune niche
niche
Adipose
Barrier
vascular-endocrine interfaceextracellular matrix remodelingadipokine signaling
Cells
macrophagesT cell subsetsmast cellseosinophils
Cytokines
TNF-alphaIL-6IL-1betaIL-10
Neuroimmune
sympathetic lipolysisstress hormone effectsinflammatory pain and fatigue loops
Graph neighborhood
Direct relationships
Adipocyte stress recruits and activates tissue macrophages
Immune niche
Tissue Ecology
Adipose tissue links energy storage to immune tone through adipocyte stress, macrophage crown-like structures, hypoxia, lipid mediators, and insulin signaling.
Dominant immune cells
Barrier systems
vascular-endocrine interfaceextracellular matrix remodelingadipokine signaling
Microbiome interactions
gut-derived endotoxin toneSCFA effects on energy and inflammationbile acid-metabolic signaling
Neuroimmune interactions
sympathetic lipolysisstress hormone effectsinflammatory pain and fatigue loops