tissue
Adipose Immune Ecosystem
Metabolic immune niche where nutrient excess, hypoxia, macrophages, and fibrosis reshape systemic inflammation
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Metabolism
Energy allocation, glycolysis, mitochondrial strain, lipid signaling, or nutrient-sensitive behavior.
Tissue ecosystem
Spatial immune niche
niche
Adipose
Barrier
Cells
Cytokines
Neuroimmune
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
Adipocyte stress recruits and activates tissue macrophages
Immune niche
Tissue Ecology
Adipose tissue links energy storage to immune tone through adipocyte stress, macrophage crown-like structures, hypoxia, lipid mediators, and insulin signaling.