reference
IgG4
Chronic-exposure and tolerance-associated IgG subclass that should not be treated as a simple food allergy marker
immunoglobulinIgG4tolerancechronic exposure
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
antibody
Systems Context
IgG4 belongs in an adaptation model: it may mark tolerance, chronic exposure, or immune engagement depending on the rest of the network.
Clinical Use
Do not use IgG4 as a stand-alone food allergy label. Interpret with symptoms, IgE, eosinophils, organ involvement, and exposure history.
Aliases
Expressed By
Class-switched B cellsPlasma cells
Targets
Functions
blocking antibody behaviorchronic exposure trackingtolerance-associated adaptationlow complement activation