reference
IgE
High-leverage type 2 antibody that arms mast cells and basophils at barrier tissues
immunoglobulinallergymast celltype 2
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
antibody
Systems Context
IgE is a threshold-setting antibody: small concentrations can create large tissue effects when receptor-bound and crosslinked.
Clinical Use
Interpret with exposure history, specific IgE, symptoms, eosinophils, and tissue pattern; total IgE alone is not diagnostic.
Aliases
Expressed By
Class-switched B cellsPlasma cells
Targets
Functions
mast cell sensitizationbasophil activationtype 2 amplificationbarrier defense