reference
FcεRI
High-affinity IgE receptor that couples sensitization to mast cell and basophil activation
IgEmast cellbasophilallergy
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
receptor
Systems Context
FcεRI turns prior antigen exposure into a lower activation threshold at barrier tissues.
Clinical Use
Central to allergic sensitization, anaphylaxis biology, and anti-IgE treatment logic.
Aliases
Expressed By
Targets
IgEallergen-IgE complexes
Functions
sensitizationdegranulationlipid mediator releasetype 2 amplification