reference
IgA
Mucosal antibody system for immune exclusion, microbiome containment, and barrier tolerance
immunoglobulinmucosamicrobiomebarrier
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
antibody
Systems Context
IgA is the antibody expression of barrier ecology: containment without constantly escalating inflammation.
Clinical Use
Low IgA changes interpretation of mucosal infection risk and some serologic tests; clinical pattern matters more than level alone.
Aliases
Expressed By
Mucosal plasma cellsLamina propria B cells
Targets
microbesfood antigenspoly-Ig receptorFcαRI