reference

C1q / classical complement

Antibody-triggered complement entry point connecting immune complexes to opsonization and inflammation

complementIgGIgMopsonization

Review layer

Last reviewed 2026-05-17

conceptualeducational

Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.

Provenance layer

External context

static reviewed map

Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.

Reactomehigh

Complement cascade

R-HSA-166658 · parent pathway

Last checked 2026-06-28

UniProthigh

Complement C1q subcomponent subunit A

P02745 · protein

Last checked 2026-06-28

pathway

Systems Context

Complement turns antibody binding into a tissue-level clearance and inflammation program.

Clinical Use

Frames immune-complex disease, antibody effector function, recurrent infection, and complement-mediated inflammation.

Aliases

C1q classical complement pathway

Expressed By

Complement systemMacrophagesLiver-derived plasma proteins

Targets

IgM complexesIgG complexesapoptotic materialpathogens

Functions

opsonizationimmune complex clearanceinflammatory amplificationmembrane attack pathway support