cytokine
IFN-gamma
Type 1 cytokine for macrophage activation, intracellular pathogen defense, and cytotoxic immune pressure
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
Provenance layer
External context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Metabolism
Energy allocation, glycolysis, mitochondrial strain, lipid signaling, or nutrient-sensitive behavior.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Cascade viewer
Source → signal → tissue behavior
Sources
Signal
IFN-gamma
Targets and effects
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
TH1 macrophage activation
Arrow shows upstream source toward receiving target.
IFN-gamma reinforces TH1 polarization and macrophage-activating context
Arrow shows upstream source toward receiving target.
Cytotoxic T cells produce IFN-gamma during antiviral and tumor responses
Arrow shows upstream source toward receiving target.
TH1 cells are a major helper source of IFN-gamma
Context link: no causal arrow.
IFN-gamma anchors TH1, cytotoxic, macrophage-activating antiviral and intracellular pathogen programs
Arrow shows upstream source toward receiving target.
NK cells are early IFN-gamma producers during viral and tumor surveillance responses
Cytokine ecology
Signal Role
IFN-gamma coordinates TH1 and cytotoxic immunity, increasing antigen presentation and macrophage antimicrobial programs.
Pathway
Source Cells
Target Cells
Inflammatory Role
Raises antigen presentation, macrophage killing, chemokine production, and cytotoxic immune tone.
Regulatory Role
Supports pathogen containment and anti-tumor surveillance.