reference
PD-1
Checkpoint receptor marking adapted T cell restraint during chronic antigen exposure
T cellcheckpointexhaustioncancer
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
receptor
Systems Context
PD-1 is often a sign that the system is limiting damage under persistent antigen pressure.
Clinical Use
Core checkpoint marker in cancer immunotherapy, chronic infection, and tolerance/exhaustion reasoning.
Aliases
Expressed By
Targets
PD-L1PD-L2