allergy
Specific IgE / total IgE interpretation
The same specific IgE value can mean different things when total IgE is low, normal, or extremely high. Ratio is not diagnostic, but it can help calibrate whether the antigen-specific signal is prominent inside the larger IgE pool.
Provenance layer
Pathway provenance context
Curated external IDs add pathway and protein context around Atlas content. They do not update the graph automatically and they are not patient-specific interpretation.
Pathway logic
Trigger to state transition
Ratio can improve interpretation, but compatible history remains the center of IgE reasoning.
Entry triggers
Key signals
Labs and data
Visual sequence
pool
Total IgE background
Total IgE represents the global IgE terrain and can rise with atopy, parasites, barrier inflammation, fungal disease, or hyper-IgE contexts.
specificity
Antigen-directed signal
Specific IgE asks how much IgE is directed toward one antigen or component, but it must match symptoms and exposure.
ratio
Fraction of the IgE pool
Specific IgE divided by total IgE can show whether the antigen-specific signal is a small trace or a large fraction of the IgE pool.
threshold
Clinical threshold context
Asthma, mast-cell threshold, cofactors, sleep debt, infection, pollen season, and medications can change expression.
Cells
B cells
plasma cells
mast cells
basophils
TH2 cells
Tissues
skin
airway
gut
sinus mucosa
Caveats
Do not diagnose allergy from IgE tests alone.
Low-level positives in high total IgE backgrounds can be misleading.
High ratio still needs compatible exposure and symptoms.
Cross-links