tissue
Spleen Immune Ecosystem
Blood-filtering immune organ coordinating encapsulated-bacteria defense, red-pulp macrophages, marginal-zone B cells, and systemic inflammatory surveillance
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
State signature
Systems profile
Tissue ecosystem
Spatial immune niche
niche
Spleen
Barrier
Cells
Cytokines
Neuroimmune
Graph neighborhood
Direct relationships
Splenic marginal-zone and follicular programs support blood-borne antigen responses
Red-pulp macrophages filter blood, recycle iron, and participate in systemic inflammatory surveillance
Immune niche
Tissue Ecology
The spleen monitors blood-borne antigen, clears damaged erythrocytes, supports marginal-zone antibody responses, and buffers systemic inflammation through macrophage, complement, B-cell, and vascular compartments.