tissue
Spleen Immune Ecosystem
Blood-filtering immune organ coordinating encapsulated-bacteria defense, red-pulp macrophages, marginal-zone B cells, and systemic inflammatory surveillance
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
Appears in response traces
State signature
Systems profile
System effects
Primary mapped axes from existing Atlas data.
Inflammation
Inflammatory alarm, recruitment, mediator release, or tissue-damaging amplification.
Tissue
Organ, barrier, stromal, vascular, or local niche behavior.
Metabolism
Energy allocation, glycolysis, mitochondrial strain, lipid signaling, or nutrient-sensitive behavior.
Tissue ecosystem
Spatial immune niche
niche
Spleen
Barrier
Cells
Cytokines
Neuroimmune
Graph neighborhood
Direct relationships
Arrow shows upstream source toward receiving target.
Splenic marginal-zone and follicular programs support blood-borne antigen responses
Context link: no causal arrow.
Red-pulp macrophages filter blood, recycle iron, and participate in systemic inflammatory surveillance
Context link: no causal arrow.
Splenic inflammatory-reflex models connect autonomic signaling with systemic cytokine restraint
Immune niche
Tissue Ecology
The spleen monitors blood-borne antigen, clears damaged erythrocytes, supports marginal-zone antibody responses, and buffers systemic inflammation through macrophage, complement, B-cell, and vascular compartments.