pathway
Regulatory Omics Layer
Genetic risk, HLA context, epigenetic memory, microRNA, extracellular vesicles, and immune-state regulation.
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
future
Systems Frame
This module gives Immune OS a future-ready layer for regulatory biology above classical cytokines: inherited constraints, chromatin memory, miRNA programs, and vesicle cargo that change how cells respond to the same signal.
Core Concepts
Key Interactions
Genetic variants can alter baseline immune thresholds, antigen presentation, complement, or cytokine signaling.
Epigenetic memory helps explain trained innate immunity, exhaustion, tolerance, and chronic adaptation.
microRNA and extracellular vesicle cargo can move regulatory instructions between tissues and immune cells.
Scenario Examples
HLA context -> antigen-presentation risk
trained immunity -> heightened innate response
tumor EVs -> immune suppression