pathway
Exposome, Nutrient & Resilience Modeling
Nutrition, air quality, pollen, weather, sunlight, medications, chemicals, sleep, stress, infection, recovery capacity, and threshold shifts.
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
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Systems Frame
This module models why the same trigger can produce different immune expression on different days by tracking cumulative exposome load, nutrient substrate, medication/chemical context, sensitization status, and recovery reserve.
Core Concepts
Key Interactions
Pollutants, wildfire smoke, pollen, and mold can amplify epithelial alarmins, oxidative stress, and sensitized-host type 2 loops.
Micronutrient and protein adequacy shape repair substrate, antibody production, antioxidant capacity, and recovery reserve without acting as stand-alone diagnoses.
Humidity, temperature, sunlight, circadian timing, and weather shifts can change airway, skin, neuroimmune, and vascular thresholds.
Medications and chemicals can cause, mask, amplify, suppress, or redirect immune signals, so timing and mechanism matter.
Scenario Examples
high pollen plus sleep debt -> mast cell reactivity
AQI plus dry air -> airway epithelial alarm
low protein reserve plus infection -> slower repair context
NSAID or ACE-inhibitor context -> mechanism-specific reaction questions