pathway
Barrier Systems Biology
Gut, lung, skin, vascular, and CNS barriers as immune-regulatory interfaces.
advancedepitheliummicrobiometight junctionsalarmins
Review layer
Last reviewed 2026-05-17
conceptualeducational
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
advanced
Systems Frame
This module presents barriers as active immune organs that translate microbiome ecology, environmental exposure, injury, and neuroimmune cues into local and systemic immune states.
Core Concepts
epitheliummicrobiometight junctionsalarminsmucusbarrier repairenvironmental load
Key Interactions
Barrier stress releases TSLP and IL-33, lowering type 2 activation thresholds.
Microbiome metabolites support tolerance and resolution.
Repeated epithelial damage can shift repair into chronic remodeling.
Scenario Examples
microbiome disruption -> TH17 shift
airway injury -> IL-33
skin barrier stress -> TSLP and itch
Build Next
barrier integrity mapmicrobiome-tolerance graphexposure load model