Visual lesson
Tolerance / Resolution
Understand immune restraint as active regulation that preserves tissue function without erasing immune readiness.
Review layer
Last reviewed 2026-05-17
Tolerance and resolution are modeled as active regulatory programs. Their meaning changes across allergy, infection, cancer, and autoimmunity.
Stage 1
Antigen without danger
Trigger
Food antigen, commensal exposure, apoptotic cell clearance, or controlled tissue repair.
Tissue Context
Gut and lymphoid tissues are biased toward tolerance when antigen arrives without destructive danger signals.
Cells
Signals
State Shift
The system learns restraint rather than escalation.
Clinical Pattern
Stable barrier function and low symptom burden despite antigen exposure.
Checkpoints
Which signal best represents regulatory restraint in this lesson?
Why is tolerance not simply immune weakness?