Visual lesson
TH2 / Allergic Ecology
Follow a type 2 immune response from barrier stress through sensitization, amplification, tissue remodeling, and resolution checkpoints.
Review layer
Last reviewed 2026-05-17
Use as a systems teaching model for type 2/allergic inflammation. Clinical interpretation depends on phenotype, tissue context, exposure history, and biomarkers.
Stage 1
Barrier alarm
Trigger
Epithelial stress from allergen, irritant, injury, infection, or barrier disruption.
Tissue Context
Skin, lung, and gut epithelium release TSLP and IL-33 when the barrier senses damage.
Cells
Signals
State Shift
The tissue shifts from tolerance toward type 2 readiness.
Clinical Pattern
Early itch, cough, mucus, flushing, or nonspecific barrier reactivity.
Checkpoints
Which cytokine is most directly tied to eosinophil survival in this lesson?
What does IgE loading on mast cells change?