pathway
Immune Tolerance / Activation Balance
The central control problem of immune health: defense, restraint, repair, adaptation, and chronic priming.
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
core
Systems Frame
This module makes the core Immune OS principle explicit: symptoms and disease states emerge from thresholds, interactions, resilience, environmental load, metabolic state, and chronic adaptation.
Core Concepts
Key Interactions
Too little activation increases infection risk; too much damages tissue.
Tolerance is active regulation, not immune absence.
Chronic adaptation can make protective programs become disease-maintaining programs.
Scenario Examples
CVID -> infection pressure and innate compensation
allergy -> barrier activation threshold shift
cancer -> immune escape and tolerance misuse