pathway
Mitochondrial Systems Biology
Energy allocation, ROS signaling, mitochondrial reserve, immune activation, fatigue biology, and recovery capacity.
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
core
Systems Frame
This module models mitochondria as dynamic signaling and energy allocation systems that shape immune activation, tolerance, exhaustion, and recovery.
Core Concepts
Key Interactions
Inflammatory activation changes mitochondrial dynamics and ROS signaling.
T cell exhaustion often includes mitochondrial strain and reduced reserve.
Macrophage inflammasome biology is linked to mitochondrial injury and metabolic stress.
Scenario Examples
sleep deprivation -> lower mitochondrial recovery
chronic infection -> T cell mitochondrial strain
metabolic inflammation -> ROS tone