pathway
Longitudinal Immune Dynamics
Acute response, resolution, trained immunity, tolerance breakdown, inflammaging, and chronic adaptation over time.
Review layer
Last reviewed 2026-05-17
Systems teaching draft. Content is structured for education and graph expansion, with formal source tagging ready for the next review pass.
core
Systems Frame
This module teaches immune behavior as trajectories. The same signal can be adaptive in hours, damaging in weeks, and remodeling in years.
Core Concepts
Key Interactions
Repeated alarmin exposure can lower activation thresholds without obvious baseline inflammation.
Failed efferocytosis keeps macrophages and neutrophils in a tissue-damaging loop.
Chronic antigen pushes T cells toward checkpoint expression and exhaustion.
Scenario Examples
microbiome disruption -> TH17 shift
chronic viral exposure -> T cell exhaustion
obesity -> macrophage activation