Systems modules

How immune cells choose glycolysis, oxidative phosphorylation, fatty acid oxidation, hypoxia programs, and exhaustion states.

Vagal, sympathetic, sensory neuron, neuropeptide, and microglial control of immune tone.

Fc glycans, lectins, aging glycans, and immune tuning through molecular surface grammar.

Acute response, resolution, trained immunity, tolerance breakdown, inflammaging, and chronic adaptation over time.

Immune cell communication through vesicle cargo, tissue stress packets, and inflammatory propagation.

Genetic risk, HLA context, epigenetic memory, microRNA, extracellular vesicles, and immune-state regulation.

Endothelium, glycocalyx, nitric oxide, leukocyte adhesion, permeability, coagulation, and immune-vascular signaling.

ApoB particle burden, LDL retention, oxidized LDL, HDL function, triglycerides, macrophages, and plaque evolution.

Energy allocation, ROS signaling, mitochondrial reserve, immune activation, fatigue biology, and recovery capacity.

Vagal tone, sympathetic load, HRV, recovery state, inflammatory reflexes, and neuroimmune threshold control.

Trends, ratios, trajectories, resilience indicators, inflammatory load, metabolic adaptation, and immune phenotyping.

Gut, lung, skin, vascular, and CNS barriers as immune-regulatory interfaces.

Integrated phenotypes across inflammation, insulin signaling, lipid biology, vascular tone, recovery, and immune state.

Nutrition, air quality, pollen, weather, sunlight, medications, chemicals, sleep, stress, infection, recovery capacity, and threshold shifts.

Drug effects, biologics, NSAIDs, ACE inhibitors, corticosteroids, antimicrobials, occupational exposures, VOCs, metals, pesticides, and immune-state interpretation.

The central control problem of immune health: defense, restraint, repair, adaptation, and chronic priming.