Clinical pattern recognition
Patterns as immune state signatures
Learn to read immune behavior through recurring constellations of cytokines, cells, tissues, suppressive signals, and longitudinal context.
TH2 / Allergic Pattern
clinical-patternIgE, mast cells, eosinophils, epithelial alarmins, and type 2 repair biology
allergyIL-4IL-5IL-13IgE
Inflammasome Pattern
clinical-patternIL-1beta, macrophage priming, danger sensing, and metabolic stress
IL-1betamacrophageNLRP3metabolic stress
Tolerance / Resolution Pattern
clinical-patternTregs, IL-10, TGF-beta, SCFAs, efferocytosis, and neural restraint
TregIL-10TGF-betaresolution
Antiviral / Interferon Pattern
clinical-patternInterferon tone, NK/CD8 surveillance, macrophage activation, and exhaustion risk
infectionviralIFN-gammaCD8NK
Neutrophilic / Pyogenic Pattern
clinical-patternCXCL8, IL-1beta, TNF-alpha, emergency myelopoiesis, and tissue containment
infectionbacterialneutrophilsCXCL8IL-1beta
TH17 / Fungal Barrier Pattern
clinical-patternIL-17 barrier recruitment, neutrophil support, mucocutaneous defense, and dysbiosis loops
infectionfungalTH17IL-17barrier